Peripheral vascular disease is an obstruction in the brain with large arteries that are NOT found. Atherosclerosis (vascular disease resulting in cholesterol build-up), inflammatory issues, embolism (vascular blockage) or the formation of blood clots may contribute to this disease. This disease, either chronic or acute, generally triggers a loss of blood supply. It also has four phases, the first being moderate walking discomfort, the second is extreme walking discomfort, the third is resting discomfort, and the fourth and final is severe resting discomfort.
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Some signs of this disease include numbness, muscle fatigue, muscle cramps suggesting low blood flow, sores or ulcers that heal slowly or not at all, changes in colour and temperature of the limbs, and reduced growth of the affected portion of the hair. Any of the causes of this condition are cigarette smoking, diabetes, total cholesterol elevations, elevated blood pressure, and multiple inflammatory mediators.
There is an extraordinarily high risk of cardiovascular episodes in people with this condition and death in the majority. With this condition, amputation is a possibility, though the risk of coronary accidents is 3-4 times higher. In the USA, in the age group of 65 or older, peripheral vascular disease affects 12-20 percent of Americans. 10 million Americans are estimated to have this disease, but only 25 percent are being treated for it. The frequency of this disease increases with age and differs considerably in prevalence. Diagnosis is of the utmost importance because there are four or five times more incidences of stroke or heart failure in persons with this condition.